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chr3:37081755 A>G

Annotations

GeneMLH1
TranscriptNM_000249.3
cDNAc.1637A>G
Proteinp.K546R
Functionmissense
Localizationexon
hg19chr3:37081755 A>G

Synonyms

TranscriptcDNAProtein
NM_001167619.2c.914A>Gp.Lys305Arg
NM_001258273.1c.914A>Gp.K305R
NM_001167617.2c.1343A>Gp.Lys448Arg
NM_001167618.2c.914A>Gp.Lys305Arg
NM_001258271.1c.1637A>Gp.K546R
NM_001258274.2c.914A>Gp.Lys305Arg
NM_001354615.1c.914A>Gp.Lys305Arg
NM_001354616.1c.914A>Gp.Lys305Arg
NM_001354617.1c.914A>Gp.Lys305Arg
NM_001354618.1c.914A>Gp.Lys305Arg
NM_001354619.1c.914A>Gp.Lys305Arg
NM_001354620.1c.1343A>Gp.Lys448Arg
NM_001354621.1c.614A>Gp.Lys205Arg
NM_001354622.1c.614A>Gp.Lys205Arg
NM_001354623.1c.614A>Gp.Lys205Arg
NM_001354624.1c.563A>Gp.Lys188Arg
NM_001354625.1c.563A>Gp.Lys188Arg
NM_001354626.1c.563A>Gp.Lys188Arg
NM_001354627.1c.563A>Gp.Lys188Arg
NM_001354628.1c.1637A>Gp.Lys546Arg
NM_001354629.1c.1538A>Gp.Lys513Arg
NM_001354630.1c.1637A>Gp.Lys546Arg

Frequency in gnomAD

GenomeExome
MAX0.00001792
AFR0
AMR0
ASJ0
EAS0
FIN0
NFE0.00001792
SAS0

ClinVar

IDPhenotypeEffect
RCV000625759.1Hereditary breast and ovarian cancer syndromeLikely pathogenic
RCV000211532.1Lynch syndromeVUS
RCV000115463.4not specifiedVUS
RCV000629933.1Hereditary nonpolyposis colon cancerVUS
RCV000566461.1Hereditary cancer-predisposing syndromeVUS
RCV000662406.1Lynch syndrome IIVUS