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HomeVariants

chr2:48026421 T>G

Annotations

GeneMSH6
TranscriptNM_000179.2
cDNAc.1299T>G
Proteinp.Y433X
Functionstop gain
Localizationexon
hg19chr2:48026421 T>G
dbSNP

Synonyms

TranscriptcDNAProtein
NM_001281492.1c.909T>Gp.Y303X
NM_001281493.1c.393T>Gp.Y131X
NM_001281494.1c.393T>Gp.Y131X

Frequency in gnomAD

GenomeExome
MAX
AFR
AMR
ASJ
EAS
FIN
NFE
SAS

ClinVar

IDPhenotypeEffect
RCV000502404.1Lynch syndromePathogenic
RCV000491745.1Hereditary cancer-predisposing syndromePathogenic