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chr17:41234451 G>A

Основные

ГенBRCA1
ТранскриптNM_007294.3
кДНКc.4327C>T
Белокp.R1443X
Функцияstop gain
Локализацияexon
hg19chr17:41234451 G>A

Синонимы

ТранскрипткДНКБелок
NM_007297.3c.4186C>Tp.R1396X
NM_007298.3c.1018C>Tp.R340X
NM_007299.3c.1018C>Tp.R340X
NM_007300.3c.4327C>Tp.R1443X
NR_027676.1n.4463C>T

Частота в gnomAD

GenomeExome
MAX0.00010.00008935
AFR0.00010
AMR00.00008935
ASJ00
EAS00
FIN00.00004486
NFE00.00001792
SAS0

ClinVar

IDФенотипЭффект
RCV000515235.1Pathogenic
RCV000235131.4not providedPathogenic
RCV000048523.11Hereditary breast and ovarian cancer syndromePathogenic
RCV000239083.1not specifiedPathogenic
RCV000019244.16Breast-ovarian cancer, familial 1Pathogenic
RCV000131880.4Hereditary cancer-predisposing syndromePathogenic
RCV000159989.2Familial cancer of breastPathogenic

HGMD

IDФенотипЭффект
CM940180Breast cancerDM